Evidence of human coronavirus HKU1 and human bocavirus in Australian children

Sloots, Theo P., McErlean, Peter, Speicher, David J., Arden, Katherine E., Nissen, Michael D. and Mackay, Ian M. (2006) Evidence of human coronavirus HKU1 and human bocavirus in Australian children. Journal of Clinical Virology, 35 1: 99-102. doi:10.1016/j.jcv.2005.09.008

Author Sloots, Theo P.
McErlean, Peter
Speicher, David J.
Arden, Katherine E.
Nissen, Michael D.
Mackay, Ian M.
Title Evidence of human coronavirus HKU1 and human bocavirus in Australian children
Journal name Journal of Clinical Virology   Check publisher's open access policy
ISSN 1386-6532
ISBN 1386-6532; 1873-5967
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1016/j.jcv.2005.09.008
Volume 35
Issue 1
Start page 99
End page 102
Total pages 4
Editor Bill Carman
Myron Levin
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2006
Language eng
Subject C1
270303 Virology
730101 Infectious diseases
1103 Clinical Sciences
Formatted abstract
Undiagnosed cases of respiratory tract disease suspected of an infectious aetiology peak during the winter months. Since studies applying molecular diagnostic assays usually report reductions in the number of undiagnosed cases of infectious disease compared to traditional techniques, we applied PCR assays to investigate the role of two recently described viruses, namely human coronavirus (HCoV) HKU1 and human bocavirus (HBoV), in a hospital-based paediatric population. Both viruses were found among Australia children with upper or lower respiratory tract disease during the autumn and winter of 2004, contributing to 21.1% of all microbial diagnoses. with individual incidences of 3.1% (HCoV-HKU1) and 5.6% (HBoV) among 324 specimens. HBoV was found to coincide with another virus in more than half of all instances and displayed a single genetic lineage, whilst HCoV-HKU1 was more likely to occur in the absence of another microbe and strains could be divided into two genetic lineages which we propose be termed HCoV-HKU1 type A and type B. Children under the age of 2 years were most at risk of infection by these viruses which contribute significantly to the microbial burden among patients with respiratory tract disease during the colder months.
© 2005 Elsevier B.V. All rights reserved.
Keyword Human coronavirus
Human bocavirus
Acute respirtory tract disease
Acute respiratory tract disease
Transcriptase-PCR assay
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 09:49:37 EST