Handedness in twins: Joint analysis of data from 35 samples

Medland, Sarah E., Duffy, David L., Wright, Margaret J., Geffen, Gina M. and Martin, Nicholas G. (2006) Handedness in twins: Joint analysis of data from 35 samples. Twin Research and Human Genetics, 9 1: 46-53. doi:10.1375/183242706776402885

Author Medland, Sarah E.
Duffy, David L.
Wright, Margaret J.
Geffen, Gina M.
Martin, Nicholas G.
Title Handedness in twins: Joint analysis of data from 35 samples
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
Publication date 2006-02
Sub-type Article (original research)
DOI 10.1375/183242706776402885
Volume 9
Issue 1
Start page 46
End page 53
Total pages 8
Editor K. M. Kirk
N. G. Martin
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2006
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Simultaneous analysis of handedness data from 35 samples of twins (with a combined sample size of 21,127 twin pairs) found a small but significant additive genetic effect accounting for 25.47% of the variance (95% confidence interval [CI] 15.69-29.51%). No common environmental influences were detected (C = 0.00; 95% Cl 0.00-7.67%), with the majority of the variance, 74.53%, explained by factors unique to the individual (95% Cl 70.49-78.67%). No significant heterogeneity was observed within studies that used similar methods to assess handedness, or across studies that used different methods. At an individual level the majority of studies had insufficient power to reject a purely unique environmental model due to insufficient power to detect familial aggregation. This lack of power is seldom mentioned within studies, and has contributed to the misconception that twin studies of handedness are not informative.
Keyword Speech
Chorion type
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 09:48:49 EST