GABAergic excitation in the basolateral amygdala

Woodruff, Alan R., Monyer, Hannah and Sah, Pankaj (2006) GABAergic excitation in the basolateral amygdala. Journal of Neuroscience, 26 46: 11881-11887. doi:10.1523/JNEUROSCI.3389-06.2006

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Author Woodruff, Alan R.
Monyer, Hannah
Sah, Pankaj
Title GABAergic excitation in the basolateral amygdala
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2006
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.3389-06.2006
Open Access Status File (Publisher version)
Volume 26
Issue 46
Start page 11881
End page 11887
Total pages 7
Editor D. C. Van Essen
Place of publication Washington, DC, USA
Publisher Society for Neuroscience
Collection year 2006
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract GABA-containing interneurons are a diverse population of cells whose primary mode of action in the mature nervous system is inhibition of postsynaptic target neurons. Using paired recordings from parvalbumin-positive interneurons in the basolateral amygdala, we show that, in a subpopulation of interneurons, single action potentials in one interneuron evoke in the postsynaptic interneuron a monosynaptic inhibitory synaptic current, followed by a disynaptic excitatory glutamatergic synaptic current. Interneuron-evoked glutamatergic events were blocked by antagonists of either AMPA/kainate or GABA(A) receptors, and could be seen concurrently in both presynaptic and postsynaptic interneurons. These results show that single action potentials in a GABAergic interneuron can drive glutamatergic principal neurons to threshold, resulting in both feedforward and feedback excitation. In interneuron pairs that both receive glutamatergic inputs after an interneuron spike, electrical coupling and bidirectional GABAergic connections occur with a higher probability relative to other interneuron pairs. We propose that this form of GABAergic excitation provides a means for the reliable and specific recruitment of homogeneous interneuron networks in the basal amygdala.
Keyword Axoaxonic
Fear
Network
Learning
Excitation
Depolarization
Neurosciences
Parvalbumin-immunoreactive Interneurons
Axo-axonic Cells
Pyramidal Cells
In-vivo
Electrical Synapses
Gaba(a) Receptors
Neurons
Hippocampus
Inhibition
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 09:42:57 EST