A cost-effectiveness analysis of heroin detoxification methods in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD)

Shanahan, M. D., Doran, C. M., Digiusto, E., Bell, J., Lintzerisa, N., White, J., Ali, R., Saunders, J. B., Mattick, R. P. and Gilmour, S. (2006) A cost-effectiveness analysis of heroin detoxification methods in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). Addictive Behaviors, 31 3: 371-387. doi:10.1016/j.addbeh.2005.05.016


Author Shanahan, M. D.
Doran, C. M.
Digiusto, E.
Bell, J.
Lintzerisa, N.
White, J.
Ali, R.
Saunders, J. B.
Mattick, R. P.
Gilmour, S.
Title A cost-effectiveness analysis of heroin detoxification methods in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD)
Journal name Addictive Behaviors   Check publisher's open access policy
ISSN 0306-4603
1873-6327
Publication date 2006-03
Sub-type Article (original research)
DOI 10.1016/j.addbeh.2005.05.016
Volume 31
Issue 3
Start page 371
End page 387
Total pages 17
Editor P. M. Miller
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2006
Language eng
Subject 340204 Health Economics
730205 Substance abuse
Abstract This economic evaluation was part of the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD) project. Data from four trials of heroin detoxification methods, involving 365 participants, were pooled to enable a comprehensive comparison of the cost-effectiveness of five inpatient and outpatient detoxification methods. This study took the perspective of the treatment provider in assessing resource use and costs. Two short-term outcome measures were used-achievement of an initial 7-day period of abstinence, and entry into ongoing post-detoxification treatment. The mean costs of the various detoxification methods ranged widely, from AUD $491 (buprenorphine-based outpatient); to AUD $605 for conventional outpatient; AUD $1404 for conventional inpatient; AUD $1990 for rapid detoxification under sedation; and to AUD $2689 for anaesthesia per episode. An incremental cost-effectiveness analysis was carried out using conventional outpatient detoxification as the base comparator. The buprenorphine-based outpatient detoxification method was found to be the most cost-effective method overall, and rapid opioid detoxification under sedation was the most costeffective inpatient method.
Keyword Heroin
Detoxification
Cost-effectiveness Analysis
Nepod
Buprenorphine
Naltrexone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Population Health Publications
 
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