A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation

Zhang, Guangmei, Schmidt, Otto and Asgari, Sassan (2006) A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation. Developmental And Comparative Immunology, 30 9: 756-764.


Author Zhang, Guangmei
Schmidt, Otto
Asgari, Sassan
Title A calreticulin-like protein from endoparasitoid venom fluid is involved in host hemocyte inactivation
Journal name Developmental And Comparative Immunology  (ERA 2012 Listed)    (ERA 2010 Rank B)   Check publisher's open access policy
Publication date 2006
Sub-type Article
DOI 10.1016/j.dci.2005.11.001
Volume number 30
Issue number 9
ISSN 0145-305X
Start page 756
End page 764
Total pages 9
Editor G.W. Warr
L.W. Clem
K. Soderhall
Place of publication Oxford, England
Publisher Pergamon-Elsevier Science Ltd
Collection year 2006
Language eng
Subject C1
270504 Invertebrate Biology
780105 Biological sciences
Abstract During oviposition, most endoparasitoid wasps inject maternal factors into their hosts to interfere with host immune reactions and ensure successful development of their progeny. Since encapsulation is a major cellular defensive response of insects against intruding parasites, parasitoids have developed numerous mechanisms to suppress the host encapsulation capability by interfering with every step in the process, including recognition, adherence and spreading. In previous studies, components of Cotesia rubecula venom were shown to inhibit melanization of host hemolymph by interfering with the prophenoloxidase activation cascade and facilitate expression of polydnavirus genes. Here we report the isolation and characterization of another venom protein with similarity to calreticulin. Results indicate that C rubecula calreticulin (CrCRT) inhibits hemocyte spreading behavior, thus preventing encapsulation of the developing parasitoid. It is possible that the protein might function as an antagonist competing for binding sites with the host hemocyte calreticulin, which mediates early-encapsulation reactions. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Cotesia Rubecula
Pieris Rapae
Venom
Calreticulin
Immune Suppression
Encapsulation
Hemocyte Spreading
Immunology
Zoology
Cell-surface Calreticulin
Pseudaletia-separata Walker
Apanteles-kariyai Watanabe
Cotesia-rubecula
Pieris-rapae
Immunoglobulin Superfamily
Immune-response
Insect
Polydnavirus
Activation
Q-Index Code C1

 
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