A Bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation

Chang, A. B., Faoagali, J., Cox, N. C., Marchant, J. M., Dean, B., Petsky, H. L. and Masters, I. B. (2006) A Bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation. Pediatric Pulmonology, 41 9: 887-892. doi:10.1002/ppul.20478

Author Chang, A. B.
Faoagali, J.
Cox, N. C.
Marchant, J. M.
Dean, B.
Petsky, H. L.
Masters, I. B.
Title A Bronchoscopic scoring system for airway secretions - Airway cellularity and microbiological validation
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
Publication date 2006
Sub-type Article (original research)
DOI 10.1002/ppul.20478
Volume 41
Issue 9
Start page 887
End page 892
Total pages 6
Editor V. Chernick
Place of publication Hoboken, U.S.A.
Publisher John Wiley & Sons
Collection year 2006
Language eng
Subject C1
321019 Paediatrics
730110 Respiratory system and diseases (incl. asthma)
Abstract There is currently no validated scoring system for quantification of airway secretions in children. A user friendly, valid scoring system of airway secretions during flexible bronchoscopy (FB) would be useful for comparative purposes in clinical medicine and research. The objective of this study was to validate our bronchoscopic secretion (BS) scoring system by examining the relationship between the amount of secretions seen at bronchoscopy with airway cellularity and microbiology. In 106 children undergoing FIB, the relationship of BS grades with bronchocalveolar lavage (BAL) cellularity and infective state (bacterial and viral infections) were examined using receptor operator curves (ROC). BAL was obtained according to European Respiratory Society guidelines; first lavage for microbiology and second lavage for cellularity Area under the ROC was significant for total cell count (TCC) and neutrophil % but not for lymphocyte %. BS grade significantly related to infection positive state (chi(2)(trend) = 5.85, P = 0,016). The area under the ROC for infection positive state versus BS grade was 0.645, 95% Cl 0.527-0.763. The BS scoring system is a valid method for quantifying airway secretions in children undergoing bronchoscopy The system related well to airway cellularity and neutrophilia, as well as to an airway infective state. However, the system is only complementary to cell counts and cultures and cannot replace these laboratory quantification techniques.
Keyword Bronchoscopy
Respiratory System
Flexible Bronchoscopy
Fiberoptic Bronchoscopy
Bronchoalveolar Lavage
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 09:40:21 EST