Transposon-free regions in mammalian genomes

Simons, Cas, Pheasant, Michael, Makunin, Igor V. and Mattick, John S. (2006) Transposon-free regions in mammalian genomes. Genome Research, 16 2: 164-172. doi:10.1101/gr4624306

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Author Simons, Cas
Pheasant, Michael
Makunin, Igor V.
Mattick, John S.
Title Transposon-free regions in mammalian genomes
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
Publication date 2006
Sub-type Article (original research)
DOI 10.1101/gr4624306
Open Access Status File (Publisher version)
Volume 16
Issue 2
Start page 164
End page 172
Total pages 9
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2006
Language eng
Abstract Despite the presence of over 3 million transposons separated on average by similar to 500 bp, the human and mouse genomes each contain almost 1000 transposon-free regions (TFRs) over 10 kb in length. The majority of human TFRs correlate with orthologous TFRs in the mouse, despite the fact that most transposons are lineage specific. Many human TFRs also overlap with orthologous TFRs in the marsupial opossum, indicating that these regions have remained refractory to transposon insertion for long evolutionary periods. Over 90% of the bases covered by TFRs are noncoding, much of which is not highly conserved. Most TFRs are not associated with unusual nucleotide composition, but are significantly associated with genes encoding developmental regulators, suggesting that they represent extended regions of regulatory information that are largely unable to tolerate insertions, a conclusion difficult to reconcile with current conceptions of gene regulation.
Keyword Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
Comparative Sequence-analysis
Noncoding Sequences
Conserved Elements
Gene Ontology
Q-Index Code C1
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 09:26:18 EST