The use of heparan sulfate to augment fracture repair in a rat fracture model

Jackson, R. A., McDonald, M. M., Nurcombe, V., Little, D. G. and Cool, S. M. (2006) The use of heparan sulfate to augment fracture repair in a rat fracture model. Journal of Orthopaedic Research, 24 4: 636-644. doi:10.1002/jor.20103


Author Jackson, R. A.
McDonald, M. M.
Nurcombe, V.
Little, D. G.
Cool, S. M.
Title The use of heparan sulfate to augment fracture repair in a rat fracture model
Journal name Journal of Orthopaedic Research   Check publisher's open access policy
ISSN 0736-0266
Publication date 2006-04
Sub-type Article (original research)
DOI 10.1002/jor.20103
Volume 24
Issue 4
Start page 636
End page 644
Total pages 9
Place of publication Oxford, England
Publisher Elsevier Sci Ltd
Collection year 2006
Language eng
Subject C1
110314 Orthopaedics
Abstract Fracture healing is a complex process regulated by numerous growth and adhesive factors expressed at specific stages during healing. The naturally occurring, cell surface-expressed sugar, heparan sulfate (HS), is known to bind to and potentiate the effects of many classes of growth factors, and as such, may be a potential candidate therapy for enhancing bone repair. This study investigated the local application of bone-derived HS in the repair of rat femoral fractures. After 2 weeks, there was a significant increase in the callus size of rats administered with 5 mu g HS compared to the control and 50 mu g HS groups, presumably due to increased trabecular bone volume rather than increased cartilage production. In addition, 5 mu g HS increased the expression of ALP, Runx2, FGF-1, IGF-II, TGF-beta 1, and VEGF. It is hypothesized that these increases resulted from changes in HS-mediated receptor/ligand interactions that increase local growth factor production to augment bone formation. The findings of this study demonstrate the anabolic potential of HS in bone repair by recruiting and enhancing the production of endogenous growth factors at the site of injury. (c) 2006 Orthopaedic Research Society.
Keyword Heparan Sulfate
Fracture Repair
Heparin-binding Growth Factors
Osteoblasts
Orthopedics
Fibroblast-growth-factor
Proteoglycans
Expression
Molecules
Defects
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 09:24:14 EST