The JNK are important for development and survival of macrophages

Himes, S. Roy, Sester, David P., Ravasi, Timothy, Cronau, Stephen L., Sasmono, Tedjo and Hume, David A. (2006) The JNK are important for development and survival of macrophages. Journal Of Immunology, 176 4: 2219-2228.


Author Himes, S. Roy
Sester, David P.
Ravasi, Timothy
Cronau, Stephen L.
Sasmono, Tedjo
Hume, David A.
Title The JNK are important for development and survival of macrophages
Journal name Journal Of Immunology   Check publisher's open access policy
ISSN 0022-1767
Publication date 2006-02-15
Sub-type Critical review of research, literature review, critical commentary
Volume 176
Issue 4
Start page 2219
End page 2228
Total pages 10
Place of publication Bethesda, M.D, U.S.A.
Publisher American Associated Press
Collection year 2006
Language eng
Subject C1
270201 Gene Expression
730101 Infectious diseases
Abstract We report in, this study that activation of the JNK by the growth factor, CSF-1 is critical for macrophage development, proliferation, and survival. Inhibition of JNK with two distinct classes of inhibitors, the pharmacological agent SP600125, or the peptide D-JNKI1 resulted in cell cycle inhibition with an arrest at the G(2)/M transition and subsequent apoptosis. JNK inhibition resulted in decreased expression of CSF-1R (c-fins) and Bcl-x(L) mRNA in mature macrophages and repressed CSF-1-dependent differentiation of bone marrow cells to macrophages. Macrophage sensitivity to JNK inhibitors may be linked to phosphorylation of the PU.1 transcription factor. Inhibition of JNK disrupted PUA binding to an element in the c-fins gene promoter and decreased promoter activity. Promoter activity could be restored by overexpression of PUA. A comparison of expression profiles of macrophages with 22 other tissue types showed that genes that signal JNK activation downstream of tyrosine kinase receptors, such as focal adhesion kinase, Nck-interacting kinase, and Rac1 and scaffold proteins are highly expressed in macrophages relative to other tissues. This pattern of expression may underlie the novel role of JNK in macrophages.
Keyword Immunology
Colony-stimulating Factor
N-terminal Kinase
Transcription Factor Pu.1
Jun Nh2-terminal Kinase
Cell-cycle Progression
Focal Adhesion Kinase
Activator Gene-transcription
Factor-i Receptor
C-jun
Signaling Pathway
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 09:21:32 EST