Survival strategy of Echinococcus multilocularis in the human host

Vuitton, Dominique Angèle, Zhang, Shao Ling, Yang, Yurong, Godot, Véronique, Beurton, Isabelle, Mantion, Georges and Bresson-Hadni, Solange (2006). Survival strategy of Echinococcus multilocularis in the human host. In: Proceedings of the International Symposium on Taeniasis/Cysticercosis and Echinococcosis with Focus on Asia and the Pacific. International Symposium on Taeniasis/Cysticercosis and Echinococcosis with Focus on Asia and the Pacific, Asahikawa, Japan, (S51-S55). 5-8 July 2005. doi:10.1016/j.parint.2005.11.007


Author Vuitton, Dominique Angèle
Zhang, Shao Ling
Yang, Yurong
Godot, Véronique
Beurton, Isabelle
Mantion, Georges
Bresson-Hadni, Solange
Title of paper Survival strategy of Echinococcus multilocularis in the human host
Conference name International Symposium on Taeniasis/Cysticercosis and Echinococcosis with Focus on Asia and the Pacific
Conference location Asahikawa, Japan
Conference dates 5-8 July 2005
Proceedings title Proceedings of the International Symposium on Taeniasis/Cysticercosis and Echinococcosis with Focus on Asia and the Pacific   Check publisher's open access policy
Journal name Parasitology International   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 2006
Sub-type Fully published paper
DOI 10.1016/j.parint.2005.11.007
ISSN 1383-5769
1873-0329
Volume 55
Issue Supp.1
Start page S51
End page S55
Total pages 5
Language eng
Abstract/Summary As exemplified by aborted calcified liver lesions commonly found in patients from endemic areas, Echinococcus multilocularis metacestodes develop only in a minority of individuals exposed to infection with the papasite. Clinical research has disclosed some aspects of the survival strategy of E. multilocularis in human hosts. Clinical observations in liver transplantation and AIDS suggest that suppression of cellular/Th1related immunity increases disease severity. Most of the studies have stressed a role for CD8+ T cells and for Interleukin-10 in the development of tolerance. A spontaneous secretion of IL-10 by the PBMC seems to be the immunological hallmark of patients with progressive forms of alveolar echinococcosis (AE). IL-10-induced inhibition of effector macrophages, but also of antigen-presenting dendritic cells, may be operating and allowing parasite growth and survival. The genetic correlates of susceptibility to infection with E. multilocularis are clearer in humans than in the mouse model. A significant link between MHC polymorphism and clinical presentation of AE has been shown, and the spontaneous secretion of IL-10 in patients with a progressive AE is higher in patients with the HLA DR3+, DQ2+ haplotype. Clustering of cases in certain families, in communities otherwise exposed to similar risk factors, also points to immuno-genetic predisposition factors that may allow the larva to escape host immunity more easily. The first stage of larval development may be crucial in producing danger signals stimulating the initial production of cytokines. Therapeutic use of Interferon alpha is an attempt to foil the survival strategy of E. multilocularis. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Subjects 1117 Public Health and Health Services
Keyword Echinococcus Multilocularis
Immune Tolerance
Immunogenetics
Hla
Interferon Alpha
Interleukin 10
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 60 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 09:17:18 EST