Recent advances in the immunology and diagnosis of echinococcosis

Zhang, Wenbao and McManus, Donald P. (2006) Recent advances in the immunology and diagnosis of echinococcosis. Fems Immunology and Medical Microbiology, 47 1: 24-41. doi:10.1111/j.1574-695X.2006.00060.x


Author Zhang, Wenbao
McManus, Donald P.
Title Recent advances in the immunology and diagnosis of echinococcosis
Journal name Fems Immunology and Medical Microbiology   Check publisher's open access policy
ISSN 0928-8244
1574-695X
Publication date 2006-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1574-695X.2006.00060.x
Volume 47
Issue 1
Start page 24
End page 41
Total pages 18
Place of publication Oxford
Publisher Blackwell Publishing
Collection year 2006
Language eng
Subject CX
Formatted abstract
Echinococcosis is a cosmopolitan zoonosis caused by adult or larval stages of cestodes belonging to the genus Echinococcus (family Taeniidae). The two major species of medical and public health importance are Echinococcus granulosus and Echinococcus multilocularis, which cause cystic echinococcosis and alveolar echinococcosis, respectively. Both cystic echinococcosis and alveolar echinococcosis are serious diseases, the latter especially so, with a high fatality rate and poor prognosis if managed inappropriately. This review highlights recent advances in immunity to infection and vaccination against both parasites in their intermediate and definitive hosts and procedures for diagnosis of cystic echinococcosis and alveolar echinococcosis, including the value of immunodiagnostic and DNA approaches. There is discussion also of progress in genomics and related technologies that is providing valuable insights on the functional biology of the Echinococcus organisms. These studies will underpin future research that will reveal a better understanding of the Echinococcus-host interplay, and suggest new avenues for the identification of additional targets for diagnosis, vaccination and chemotherapy.
Keyword Echinococcus granulosus
Echinococcus multilocularis
echinococcosis
immunity to infection
vaccination
diagnosis
immunodiagnosis
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 09:09:22 EST