Parkinson's disease and family history

Sellbach, Annabella N., Boyle, Richard S., Silburn, Peter A. and Mellick, George D. (2006) Parkinson's disease and family history. Parkinsonism & Related Disorders, 12 7: 399-409. doi:10.1016/j.parkreldis.2006.03.002


Author Sellbach, Annabella N.
Boyle, Richard S.
Silburn, Peter A.
Mellick, George D.
Title Parkinson's disease and family history
Journal name Parkinsonism & Related Disorders   Check publisher's open access policy
ISSN 1353-8020
1873-5126
Publication date 2006-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.parkreldis.2006.03.002
Volume 12
Issue 7
Start page 399
End page 409
Total pages 11
Place of publication Kiddlington, Oxford, U.K.
Publisher Elsevier
Collection year 2006
Language eng
Subject CX
1103 Clinical Sciences
Abstract The study of family history in Parkinson's disease (PD) has resulted in considerable debate over the role of genetic factors in the development of PD. Despite this, family history is consistently identified as an independent risk factor for PD. A multifactorial disease process in which genetic, environmental and lifestyle factors culminate in overall risk seems most likely. This article reviews existing studies of familial aggregation in PD. Recent insights into rare genetic causes of PD have affirmed the importance of ongoing family history research. Future efforts should emphasise well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up. © 2006 Elsevier Ltd. All rights reserved.
Keyword Parkinson's disease
Parkinsonism
Family history
Familial aggregation
Genetics
Epidemiology
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 09:04:41 EST