Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli

Power, P. M., Seib, K. L. and Jennings, M. P. (2006) Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli. Biochemical And Biophysical Research Communications, 347 4: 904-908. doi:10.1016/j.bbrc.2006.06.182


Author Power, P. M.
Seib, K. L.
Jennings, M. P.
Title Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli
Journal name Biochemical And Biophysical Research Communications   Check publisher's open access policy
ISSN 0006-291X
1090-2104
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.bbrc.2006.06.182
Volume 347
Issue 4
Start page 904
End page 908
Total pages 5
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2006
Language eng
Subject C1
270301 Bacteriology
730101 Infectious diseases
Abstract Pili (type IV fimbriae) of Neisseria meningitidis are glycosylated by the addition of O-linked sugars. Recent work has shown that PglF, a protein with homology to O-antigen 'flippases', is required for the biosynthesis of the pilin-linked glycan and suggests pilin glycosylation occurs in a manner analogous to the wzy-dependent addition of O-antigen to the core-LPS. O-Antigen ligases are crucial in this pathway for the transfer of undecraprenol-linked sugars to the LPS-core in Gram-negative bacteria. An O-antigen ligase homologue, pglL, was identified in N. meningitidis. PglL mutants showed no change in LPS phenotypes but did show loss of pilin glycosylation, confirming PglL is essential for pilin O-linked glycosylation in N. meningitidis. (c) 2006 Elsevier Inc. All rights reserved.
Keyword Neisseria Meningitidis
Pilin
Glycosylation
O-antigen Ligase
pgIL
wzy-dependent O-antigen Biosynthesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 09:03:41 EST