Non-coding RNA

Mattick, John S. and Makunin, Igor V. (2006) Non-coding RNA. Human Molecular Genetics, 15 suppl 1: R17-R29. doi:10.1093/hmg/ddl046

Author Mattick, John S.
Makunin, Igor V.
Title Non-coding RNA
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 0964-6906
Publication date 2006-04-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1093/hmg/ddl046
Volume 15
Issue suppl 1
Start page R17
End page R29
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2006
Language eng
Abstract The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. Although it has been generally assumed that most genetic information is transacted by proteins, recent evidence suggests that the majority of the genomes of mammals and other complex organisms is in fact transcribed into ncRNAs, many of which are alternatively spliced and/or processed into smaller products. These ncRNAs include microRNAs and snoRNAs (many if not most of which remain to be identified), as well as likely other classes of yet-to-be-discovered small regulatory RNAs, and tens of thousands of longer transcripts (including complex patterns of interlacing and overlapping sense and antisense transcripts), most of whose functions are unknown. These RNAs (including those derived from introns) appear to comprise a hidden layer of internal signals that control various levels of gene expression in physiology and development, including chromatin architecture/epigenetic memory, transcription, RNA splicing, editing, translation and turnover. RNA regulatory networks may determine most of our complex characteristics, play a significant role in disease and constitute an unexplored world of genetic variation both within and between species.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 739 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 877 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 09:02:12 EST