Oscillatory regulation of hes1: Discrete stochastic delay modelling and simulation

Barrio, Manuel, Burrage, Kevin, Leier, André and Tian, Tianhai (2006) Oscillatory regulation of hes1: Discrete stochastic delay modelling and simulation. Plos Computational Biology, 2 9: 1017-1030. doi:10.1371/journal.pcbi.0020117


Author Barrio, Manuel
Burrage, Kevin
Leier, André
Tian, Tianhai
Title Oscillatory regulation of hes1: Discrete stochastic delay modelling and simulation
Journal name Plos Computational Biology   Check publisher's open access policy
ISSN 1553-734X
Publication date 2006-09-08
Sub-type Article (original research)
DOI 10.1371/journal.pcbi.0020117
Open Access Status DOI
Volume 2
Issue 9
Start page 1017
End page 1030
Total pages 14
Editor Peter Hunter
Place of publication San Francisco, CA, United Sates
Publisher Public Library Science
Collection year 2006
Language eng
Subject 239901 Biological Mathematics
230116 Numerical Analysis
279999 Biological Sciences not elsewhere classified
780101 Mathematical sciences
780105 Biological sciences
Abstract Discrete stochastic simulations are a powerful tool for understanding the dynamics of chemical kinetics when there are small-to-moderate numbers of certain molecular species. In this paper we introduce delays into the stochastic simulation algorithm, thus mimicking delays associated with transcription and translation. We then show that this process may well explain more faithfully than continuous deterministic models the observed sustained oscillations in expression levels of hes1 mRNA and Hes1 protein.
Keyword Biochemical Research Methods
Mathematics, Interdisciplinary Applications
Gene-expression
Vertebrate Segmentation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 09:01:45 EST