Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential

Schroeder, C. I. and Lewis, R. J. (2006) Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. Marine Drugs, 4 3: 193-214. doi:10.3390/md403193


Author Schroeder, C. I.
Lewis, R. J.
Title Omega-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential
Formatted title
ω-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential
Journal name Marine Drugs   Check publisher's open access policy
ISSN 1660-3397
Publication date 2006-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/md403193
Open Access Status DOI
Volume 4
Issue 3
Start page 193
End page 214
Total pages 22
Editor Peter Proksch
Place of publication Basel, Switzerland
Publisher Molecular Diversity Preservation International
Collection year 2006
Language eng
Subject C1
320504 Toxicology (incl. Clinical Toxicology)
780103 Chemical sciences
Abstract Highly selective N-type voltage-gated calcium (Ca-V) channel inhibitors from cone snail venom (the omega-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain. Earlier in 2005, Prialt ( Elan) or synthetic omega-conotoxin MVIIA, was the first omega-conotoxin to be approved by Food and Drug Administration for human use. This review compares the action of three omega-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships and potential as leads for the design of improved N-type therapeutics that are more useful in the treatment of chronic pain.
Keyword Omega-conotoxin
Structure-activity Relationship
Pain
Chemistry, Medicinal
Calcium-channel Blocker
Mu-opioid-receptor
Relaxation Matrix Analysis
Dependent Ca2+ Channels
N-type
Neuropathic Pain
P-type
3-dimensional Structure
Transmitter Release
G-protein
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 09:00:40 EST