Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

Hugo, H, Cures, A, Suraweera, N, Drabsch, Y, Purcell, D, Mantamadiotis, T, Phillips, W, Dobrovic, A., Zupi, G, Gonda, TJ, Iacopetta, B and Ramsay, RG (2006) Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes & Cancer, 45 12: 1143-1154. doi:10.1002/gcc.20378

Author Hugo, H
Cures, A
Suraweera, N
Drabsch, Y
Purcell, D
Mantamadiotis, T
Phillips, W
Dobrovic, A.
Zupi, G
Gonda, TJ
Iacopetta, B
Ramsay, RG
Title Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers
Journal name Genes Chromosomes & Cancer   Check publisher's open access policy
ISSN 1045-2257
Publication date 2006
Sub-type Article (original research)
DOI 10.1002/gcc.20378
Open Access Status
Volume 45
Issue 12
Start page 1143
End page 1154
Total pages 12
Editor F. Mitelman
J. D. Rowley
T. Fioretos et al.
Place of publication United States
Publisher John Wiley & Sons, Inc.
Collection year 2006
Language eng
Subject C1
270201 Gene Expression
730108 Cancer and related disorders
Abstract Although MYB overexpression in colorectal cancer (CRC) is known to be a prognostic indicator for poor survival, the basis for this overexpression is unclear. Among multiple levels of MYB regulation, the most dynamic is the control of transcriptional elongation by sequences within intron I. The authors have proposed that this regulatory sequence is transcribed into an RNA stem-loop and 19-residue polyuridine tract, and is subject to mutation in CRC. When this region was examined in colorectal and breast carcinoma cell lines and tissues, the authors found frequent mutations only in CRC. It was determined that these mutations allowed increased transcription compared with the wild type sequence. These data suggest that this MYB regulatory region within intron I is subject to mutations in CRC but not breast cancer, perhaps consistent with the mutagenic insult that occurs within the colon and not mammary tissue. In CRC, these mutations may contribute to MYB overexpression, highlighting the importance of noncoding sequences in the regulation of key cancer genes. (c) 2006 Wiley-Liss, Inc.
Keyword Oncology
Genetics & Heredity
Erythroleukemia Cell-differentiation
Clinical Tumor Specimens
Human Colorectal-cancer
Microsatellite Instability
Constitutive Expression
Stimulating Factor
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 08:57:12 EST