Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians

Wang, Zhiqiang and Hoy, Wendy E. (2006) Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians. International Journal of Epidemiology, 35 5: 1331-1335.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
zw_ije_06.pdf zw_ije_06.pdf Click to show the corresponding preview/stream application/pdf 62.26KB 461

Author Wang, Zhiqiang
Hoy, Wendy E.
Title Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 0300-5771
1464-3685
Publication date 2006-06-01
Sub-type Article (original research)
DOI 10.1093/ije/dyl115
Volume 35
Issue 5
Start page 1331
End page 1335
Total pages 5
Editor G. D. Smith
S. Ebrahim
Place of publication Oxford, U.K.
Publisher Oxford University Press
Collection year 2006
Language eng
Subject 321200 Public Health and Health Services
321202 Epidemiology
321207 Indigenous Health
C1
Formatted abstract  BACKGROUND:
Aboriginal Australians experience a higher risk of diabetes than the general Australian population. In this paper, we conducted a nested case-control study to determine whether the presence of microalbuminuria and macroalbuminuria is associated with the development of diabetes among diabetes-free Aboriginal people at baseline.

METHODS:

Urine albumin to creatinine ratios (ACRs) were obtained from 882 Aboriginal people aged 20-74 years from one community. Among them 750 were free of either clinical known diabetes or newly diagnosed diabetes according to WHO 1999 criteria. Over an 11 year follow-up period, 117 participants developed diabetes. They were defined as cases. Each case was matched by an individual control with same sex and body mass index (BMI) category, and age within 2 years. Conditional logistic regression was used to assess the association between albuminuria and diabetes.

RESULTS:

The baseline level of ACR was significantly higher among cases than among controls. The odds ratios for future diabetes were 2.36 [95% confidence interval (95% CI) 1.01-5.50] and 3.27 (95% CI 1.38-7.77) for middle and upper tertiles, respectively, with adjustment for age, BMI, serum total cholesterol, serum C-reactive protein values, and fasting plasma glucose at the baseline. The adjusted odds ratios were 1.90 (95% CI 0.88-4.06) and 2.51 (95% CI 1.08-5.87) for those with microalbuminuria and macroalbuminuria, respectively.

CONCLUSIONS:
The presence of microalbuminuria and macroalbuminuria predicts diabetes independent of other known risk markers of development of type 2 diabetes in Aboriginal people.
Keyword diabetes
minorities
albuminuria
case control
Aboriginal health
epidemiology
Coronary-heart-disease
Body-mass Index
Metabolic Syndrome
Insulin-resistance
Renal-disease
Natural-history
Microalbuminuria
People
Community
Mellitus
Q-Index Code C1
Additional Notes This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version of Wang, Z. and Hoy, Wendy E. (2006) Albuminuria as a marker of the risk of developing type 2 diabetes in non-diabetic Aboriginal Australians, International Journal of Epidemiology (forthcoming) is available online at: http://dx.doi.org/10.1093/ije/dyl115 Copyright 2006 Oxford Journals. All rights reserved.

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 274 Abstract Views, 468 File Downloads  -  Detailed Statistics
Created: Thu, 07 Sep 2006, 10:00:00 EST by Zhiqiang Wang on behalf of School of Medicine