In utero and postnatal maternal smoking and asthma in adolescence

Alati, Rosa, Al Mamun, Abdullah, O'Callaghan, Michael, Najman, Jake M. and Williams, Gail M. (2006) In utero and postnatal maternal smoking and asthma in adolescence. Epidemiology, 17 2: 138-144. doi:10.1097/01.ede.0000198148.02347.33

Author Alati, Rosa
Al Mamun, Abdullah
O'Callaghan, Michael
Najman, Jake M.
Williams, Gail M.
Title In utero and postnatal maternal smoking and asthma in adolescence
Journal name Epidemiology   Check publisher's open access policy
ISSN 1044-3983
Publication date 2006-03
Sub-type Article (original research)
DOI 10.1097/01.ede.0000198148.02347.33
Volume 17
Issue 2
Start page 138
End page 144
Total pages 7
Editor Dr Allen J. Wilcox
Place of publication Philadelphia, P.A., U.S.A.
Publisher Lippincott Williams & Wilkins
Collection year 2006
Language eng
Subject C1
321204 Mental Health
730211 Mental health
Abstract Background: Asthma in early childhood has been associated with maternal smoking during pregnancy and parental smoking soon after birth. However, less is known about these exposures and the development of asthma symptoms in adolescence. Methods: Data were taken from the Mater University Study, of Pregnancy, a large birth cohort study of mothers and children enrolled in Brisbane, Australia, beginning in 1981. Smoking was assessed at 2 stages during pregnancy and at the 6-month and 5-year follow-up visits. Asthma was assessed from maternal reports that were provided when the child was age 14 years. We conducted multivariable multinomial logistic regression analyses to assess the effect of maternal smoking on asthma symptoms. Results: There was a strong sex interaction such that girls whose mothers had smoked heavily (20 or more cigarettes per day) in pregnancy and at the 6-month follow up had increased odds of experiencing asthma symptoms at age 14 (odds ratio = 1.96; 95% confidence interval = 1.25-3.08). The contribution of heavy smoking during pregnancy appeared to be stronger than heavy smoking after the birth. No similar associations were seen for boys. Conclusion: Female adolescents whose mothers smoked heavily during the fetal period and the early months of life have increased risk of asthma symptoms in adolescence. In utero exposure to heavy smoking was found to have a stronger effect than postnatal environmental tobacco exposure.
Keyword Public, Environmental & Occupational Health
Environmental Tobacco-smoke
Childhood Lung-function
Early-onset Asthma
Parental Smoking
Passive Smoking
Respiratory Symptoms
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 08:49:34 EST