Evaluation and outcome of young children with chronic cough

Marchant, Julie M., Masters, I. Brent, Taylor, Simone M., Cox, Nancy C., Seymour, Greg J. and Chang, Anne B. (2006) Evaluation and outcome of young children with chronic cough. Chest, 129 5: 1132-1141. doi:10.1378/chest.129.5.1132

Author Marchant, Julie M.
Masters, I. Brent
Taylor, Simone M.
Cox, Nancy C.
Seymour, Greg J.
Chang, Anne B.
Title Evaluation and outcome of young children with chronic cough
Journal name Chest   Check publisher's open access policy
ISSN 0012-3692
Publication date 2006
Sub-type Article (original research)
DOI 10.1378/chest.129.5.1132
Volume 129
Issue 5
Start page 1132
End page 1141
Total pages 10
Editor P. Goorsky
R. Irwin
S. Welch
J. Rice
Place of publication Northbrook
Publisher Amer Coll Chest Physicians
Collection year 2006
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Formatted abstract
Objective: To evaluate the use of an adult-based algorithmic approach to chronic cough in a cohort of children with a history of > 3 weeks of cough and to describe the etiology of chronic cough in this cohort.

A prospective cohort study of children referred to a tertiary hospital with a history of > 3 weeks of cough between June 2002 and June 2004. All included children followed a pathway of investigation (including flexible bronchoscopy and evaluation of airway cytology via BAL) until diagnosis was made and/or their cough resolved.

Results: In our cohort of 108 young children (median age 2.6 years), the majority had wet cough (n = 96; 89%), and BAL fluid samples obtained during bronchoscopy led to a diagnosis in 45.4% (n =49). The most common final diagnosis was protracted bacterial bronchitis (n =43; 39.8%). These patients had neutrophil levels on BAL samples that were significantly higher than those in other diagnostic groups (p < 0.0001). Asthma, gastroesophageal reflux disease (GERD), and upper airway cough syndrome (UACS), which are common causes of chronic cough in adults, were found in < 10%of the cohort (n = 10).

Conclusions: The adult-based anatomic pathway, which involves the investigation and treatment of patients with asthma, GERD, and UACS first is largely unsuitable for use in the management of chronic cough in young children as the common etiologies of chronic cough in children are different from those in adults.

Keyword Airway Inflammation
Chronic Cough
Respiratory System
Persistent Cough
Gastroesophageal Reflux
Bronchoalveolar Lavage
Diagnostic Evaluation
Respiratory Symptoms
Key Components
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 135 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 166 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 08:43:40 EST