Engineered T cell receptors and their potential in molecular medicine

Miles, John J., Silins, Sharon L. and Burrows, Scott R. (2006) Engineered T cell receptors and their potential in molecular medicine. Current Medicinal Chemistry, 13 23: 2725-2736. doi:10.2174/092986706778521959


Author Miles, John J.
Silins, Sharon L.
Burrows, Scott R.
Title Engineered T cell receptors and their potential in molecular medicine
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
Publication date 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/092986706778521959
Volume 13
Issue 23
Start page 2725
End page 2736
Total pages 12
Place of publication Sharjah
Publisher Bentham Science Publ Ltd
Collection year 2006
Language eng
Subject CX
320400 Medical Microbiology
320402 Medical Virology
Abstract T cell receptors are among the most specific biological structures found in nature and are therefore excellent candidates for the molecular targeting of antigen. It is becoming increasingly apparent that common sets of T cell receptors are frequently used in humans to combat pathogen and cancer derived threats. Given that many of these conserved T cell receptors have high affinity for their target ligands, there is potential to amass virtual banks of “off-the-shelf” receptors for use in a wide range of immunotherapeutic strategies. Additionally, such T cell receptors could become basic blueprints for artificial enhancement through mutagenesis, thereby creating an even better 3-dimensional fit for their cognate targets. Indeed, preliminary approaches using both “natural” and “supernatural” T cell receptors have shown promise in treating autoimmunity and malignancy. This review will discuss these studies and other approaches through which T cell receptors can be exploited in immunodiagnostics, pathogen control and gene therapy.
Keyword T cell receptor
immunotherapy
major histocompatibility complex
human leucocyte antigens
Q-Index Code CX

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Wed, 15 Aug 2007, 08:42:43 EST