Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing

Blazkiewicz, P., Blazkiewicz, K., Verhaege, A., Anissimov, Y. G., Roberts, M. S. and Zvyagin, A. V. (2006) Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing. Journal Of Biomedical Optics, 11 1: 014033.1-014033.7. doi:10.1117/1.2166086

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Author Blazkiewicz, P.
Blazkiewicz, K.
Verhaege, A.
Anissimov, Y. G.
Roberts, M. S.
Zvyagin, A. V.
Title Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing
Journal name Journal Of Biomedical Optics   Check publisher's open access policy
ISSN 1083-3668
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1117/1.2166086
Open Access Status File (Publisher version)
Volume 11
Issue 1
Start page 014033.1
End page 014033.7
Total pages 7
Editor Bruce J. Tromberg
Karolyn Labes
Place of publication Bellingham, WA, United States
Publisher S P I E - International Society for Optical Engineering
Collection year 2006
Language eng
Formatted abstract
A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable continuous in vivo drug sensing, removing the necessity for complex microdialysis systems. We use a biological phantom to examine the reliable detection of a fluorescence signal from small dye molecules in the presence of large fluorophores and scatterers. We find that spectral artefacts arising from scatterers and large fluorophores are substantially suppressed, simplifying the spectral analysis. In addition, the measured sampling rate of 157 s is superior to existing in vivo tissue assaying techniques such as microdialysis, which can take tens of minutes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article # 014033

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Created: Wed, 15 Aug 2007, 08:37:20 EST