Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment

Seib, K. L., Wu, H. J., Kidd, S. P., Apicella, M. A., Jennings, M. P. and McEwan, A. G. (2006) Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment. Microbiology And Molecular Biology Reviews, 70 2: 344-361. doi:10.1128/MMBR.00044-05

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Author Seib, K. L.
Wu, H. J.
Kidd, S. P.
Apicella, M. A.
Jennings, M. P.
McEwan, A. G.
Title Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment
Journal name Microbiology And Molecular Biology Reviews   Check publisher's open access policy
ISSN 1092-2172
1098-5557
Publication date 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/MMBR.00044-05
Open Access Status File (Publisher version)
Volume 70
Issue 2
Start page 344
End page 361
Total pages 19
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2006
Language eng
Abstract Neisseria gonorrhoeae is a host-adapted pathogen that colonizes primarily the human genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species as a consequence of localized inflammatory responses in the urethra of males and endocervix of females and also of the activity of commensal lactobacilli in the vaginal flora. This review describes recent advances in the understanding of defense systems against oxidative stress in N. gonorrhoeae and shows that while some of its defenses have similarities to the paradigm established with Escherichia coli, there are also some key differences. These differences include the presence of a defense system against superoxide based on manganese ions and a glutathione-dependent system for defense against nitric oxide which is under the control of a novel MerR-like transcriptional regulator. An understanding of the defenses against oxidative stress in N. gonorrhoeae and their regulation may provide new insights into the ways in which this bacterium survives challenges from polymorphonuclear leukocytes and urogenital epithelial cells.
Keyword Microbiology
Outer-membrane Protein
Cytochrome-c-oxidase
Methionine Sulfoxide Reductase
Alkyl Hydroperoxide Reductase
Escherichia-coli K-12
Lipid-modified Azurin
Mitochondrial Respiratory-chain
Global Transcriptional Response
Containing Superoxide-dismutase
Glutathione-peroxidase Homolog
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 15 Aug 2007, 08:35:50 EST