Controlled longitudinal study of bone mass accrual in children and adolescents with cystic fibrosis

Buntain, H. M., Schluter, P. J., Bell, S. C., Greer, R. M., Wong, J. C. H., Batch, J., Lewindon, P. and Wainwright, C. E. (2006) Controlled longitudinal study of bone mass accrual in children and adolescents with cystic fibrosis. Thorax, 61 2: 146-154. doi:10.1136/thx.2005.046516

Author Buntain, H. M.
Schluter, P. J.
Bell, S. C.
Greer, R. M.
Wong, J. C. H.
Batch, J.
Lewindon, P.
Wainwright, C. E.
Title Controlled longitudinal study of bone mass accrual in children and adolescents with cystic fibrosis
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
Publication date 2006-02
Sub-type Article (original research)
DOI 10.1136/thx.2005.046516
Volume 61
Issue 2
Start page 146
End page 154
Total pages 9
Editor D. Mitchell
S. Johnston
J. A. Wedzicha
Place of publication London, U.K.
Publisher B M J Publishing Group
Collection year 2006
Language eng
Subject C1
110203 Respiratory Diseases
111403 Paediatrics
Formatted abstract
Background: A study was undertaken to observe the gains in bone mass in children and adolescents with cystic fibrosis (CF) over 24 months and to examine the relationship between areal bone mineral density (aBMD) and associated clinical parameters including physical activity, nutrition, and 25-hydroxyvitamin D (25OHD). Methods: Areal BMD of the total body (TB), lumbar spine (LS), and total moral neck (FNt) were.. repeatedly measured in 85 subjects aged 5-18 years with CF and 100 age and sex matched controls over 2 years. At each visit anthropometric variables, nutritional parameters, pubertal status, disease severity, physical activity, dietary calcium, caloric intake, and serum 25OHD were assessed and related to aBMD. Results: After adjusting for age, sex, and height Z-score, gains in LS aBMD in children (5-10 years) and TB and FNt aBMD in adolescents (11-18 years) with CF were significantly less than in controls. Lean tissue mass was significantly associated with TB and LS aBMD gains in children and adolescents and explained a significant proportion of the aBMD deficit observed. Lung function parameters were significantly associated with aBMD gains in adolescents with CF. Conclusions: Inadequate bone mass accrual during childhood and adolescence contributes to the low bone mass observed in adults with CF. Accounting for the height discrepancy which is frequently observed in those with CF, in addition to age and sex, is important when assessing low bone mass in children and adolescents with CF. To optimise an individual's potential to acquire maximal bone mass, it is necessary to maximise nutritional status and limit the progression of chronic suppurative lung disease.
Keyword Respiratory System
Mineral Density
Controlled Trial
Q-Index Code C1

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 45 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 08:33:56 EST