Citrinin revisited: from monomers to dimers and beyond

Clark, Benjamin R., Capon, Robert J., Lacey, Ernest, Tennant, Shaun and Gill, Jennifer H. (2006) Citrinin revisited: from monomers to dimers and beyond. Organic & Biomolecular Chemistry, 4 8: 1520-1528. doi:10.1039/b600960c

Author Clark, Benjamin R.
Capon, Robert J.
Lacey, Ernest
Tennant, Shaun
Gill, Jennifer H.
Title Citrinin revisited: from monomers to dimers and beyond
Journal name Organic & Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
Publication date 2006
Sub-type Article (original research)
DOI 10.1039/b600960c
Open Access Status Not Open Access
Volume 4
Issue 8
Start page 1520
End page 1528
Total pages 9
Editor Dr Vikki Allen
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2006
Language eng
Abstract Detailed chemical analysis of the solid phase fermentation of an Australian Penicillium citrinum isolate has returned the known compounds citrinin (1), phenol A acid (6), dihydrocitrinone (7) and dihydrocitrinin (8), together with a novel cytotoxic dimer, dicitrinin A (5). Dicitrinin A (5) was determined to be a dimerised artefact of the major co-metabolite citrinin, and its structure solved by spectroscopic analysis and chemical modi. cation. Analysis of the products encountered during the controlled decomposition of citrinin led to the discovery of additional citrinin dimers and delineated a plausible mechanistic pathway linking all monomeric and dimeric citrinin degradation products.
Keyword Citrinin
Chemistry, Organic
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 08:30:57 EST