Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses

McCurdy, Richard D., Feron, Francois, Perry, Chris, Chant, David C., McLean, Duncan, Matigian, Nick, Hayward, Nicholas K., McGrath, John J. and Mackay-Sim, Alan (2006) Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophrenia Research, 82 2-3: 163-173. doi:10.1016/j.schres.2005.10.012


Author McCurdy, Richard D.
Feron, Francois
Perry, Chris
Chant, David C.
McLean, Duncan
Matigian, Nick
Hayward, Nicholas K.
McGrath, John J.
Mackay-Sim, Alan
Title Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.schres.2005.10.012
Open Access Status
Volume 82
Issue 2-3
Start page 163
End page 173
Total pages 11
Editor H. A. Nasrallah
L. E. Delisi
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2006
Language eng
Subject C1
321204 Mental Health
730211 Mental health
Abstract We previously demonstrated that olfactory cultures front individuals with schizophrenia had increased cell proliferation compared to Cultures from healthy controls. The aims of this study were to (a) replicate this observation in a new group Of individuals with schizophrenia, (b) examine the specificity of these findings by including individuals with bipolar I disorder and (c) explore gene expression differences that may underlie cell cycle differences in these diseases. Compared to controls (n = 10), there was significantly more mitosis in schizophrenia patient cultures (it = 8) and significantly more cell death in the bipolar I disorder patient cultures (n=8). Microarray data showed alterations to the cell cycle and phosphatidylinositol signalling pathways in schizophrenia and bipolar I disorder, respectively. Whilst caution is required in the interpretation of the array results, the study provides evidence indicating that cell proliferation and cell death in olfactory neuroepithelial cultures is differentially altered in schizophrenia and bipolar disorder. (c) 2005 Elsevier B.V. All rights reserved.
Keyword Schizophrenia
Bipolar I Disorder
Olfactory Epithelium
Neurogenesis
Microarray
Neurodevelopment
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 08:29:45 EST