Calcium transport and signaling in the mammary gland: Targets for breast cancer

Lee, W. J., Monteith, G. R. and Roberts-Thomson, S. J. (2006) Calcium transport and signaling in the mammary gland: Targets for breast cancer. Biochimica Et Biophysica Acta-reviews On Cancer, 1765 2: 235-255. doi:10.1016/j.bbcan.2005.12.001


Author Lee, W. J.
Monteith, G. R.
Roberts-Thomson, S. J.
Title Calcium transport and signaling in the mammary gland: Targets for breast cancer
Journal name Biochimica Et Biophysica Acta-reviews On Cancer   Check publisher's open access policy
ISSN 0304-419X
Publication date 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbcan.2005.12.001
Volume 1765
Issue 2
Start page 235
End page 255
Total pages 21
Place of publication Amsterdam
Publisher Elsevier
Collection year 2006
Language eng
Subject C1
320501 Pharmaceutical Sciences and Pharmacy
780105 Biological sciences
Abstract The mammary gland is subjected to extensive calcium loads during lactation to support the requirements of milk calcium enrichment. Despite the indispensable nature of calcium homeostasis and signaling in regulating numerous biological functions, the mechanisms by which systemic calcium is transported into milk by the mammary gland are far from completely understood. Furthermore, the implications of calcium signaling in terms of reaulating proliferation, differentiation and apoptosis in the breast are currently uncertain. Deregulation of calcium homeostasis and signaling is associated with mammary gland pathophysiology and as such, calcium transporters, channels and binding proteins represent potential drug targets for the treatment of breast cancer. (c) 2005 Elsevier B.V. All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
Oncology
Plasma-membrane Ca2+-atpase
Yeast Secretory Pathway
Hailey-hailey-disease
Metastasis-inducing Protein
Capacitative Ca2+ Entry
Hormone-related Protein
Estrogen-receptor-beta
Selective Ion-channel
Endoplasmic-reticulum
Intracellular Calcium
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Pharmacy Publications
 
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