Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples

Holliday, Elizabeth G., Handoko, Herlina Y., James, Michael R., McGrath, J. J., Nertney, Deborah A., Tirupati, Sujit, Thara, Rangaswamy, Levinson, Douglas F., Hayward, Nicholas K., Mowry, Bryan J. and Nyholt, Dale R. (2006) Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples. Twin Research and Human Genetics, 9 4: 531-539.


Author Holliday, Elizabeth G.
Handoko, Herlina Y.
James, Michael R.
McGrath, J. J.
Nertney, Deborah A.
Tirupati, Sujit
Thara, Rangaswamy
Levinson, Douglas F.
Hayward, Nicholas K.
Mowry, Bryan J.
Nyholt, Dale R.
Title Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
1369-0523
Publication date 2006
Sub-type Article (original research)
DOI 10.1375/183242706778025035
Volume 9
Issue 4
Start page 531
End page 539
Total pages 9
Editor K. M. Kirk
N. G. Martin
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2006
Language eng
Subject 321204 Mental Health
730211 Mental health
Formatted abstract Numerous studies have reported association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. However, the pattern of results is complex and to date, no specific risk marker or haplotype has been consistently identified. The number of single nucleotide polymorphisms (SNPs) tested in these studies has ranged from 5 to 20. We attempted to replicate previous findings by testing 16 SNPs in samples of 41 Australian pedigrees, 194 Australian cases and 180 controls, and 197 Indian pedigrees. No globally significant evidence for association was observed in any sample, despite power calculations indicating sufficient power to replicate several previous findings. Possible explanations for our results include sample differences in background linkage dis-equilibrium and/or risk allele effect size, the presence of multiple risk alleles upon different haplotypes, or the presence of a single risk allele upon multiple haplotypes. Some previous associations may also represent false positives. Examination of Caucasian HapMap phase II genotype data spanning the DTNBP1 region indicates upwards of 40 SNPs are required to satisfactorily assess all nonredundant variation within DTNBP1 and its potential regulatory regions for association with schizophrenia. More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia.
Keyword Genetics & Heredity
Obstetrics & Gynecology
Single-nucleotide Polymorphisms
Linkage Disequilibrium
Dtnbp1 Gene
Genome Scan
Risk Haplotype
Dysbindin Gene
6p22.3 Gene
Expression
Locus
Identification
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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