Are branched chain fatty acids the natural substrates for P450(BM3)?

Cryle, Max J., Espinoza, Rocio D., Smith, Sarah J., Matovic, Nicholas J. and De Voss, James J. (2006) Are branched chain fatty acids the natural substrates for P450(BM3)?. Chemical Communications, 22: 2353-2355. doi:10.1039/b601202g


Author Cryle, Max J.
Espinoza, Rocio D.
Smith, Sarah J.
Matovic, Nicholas J.
De Voss, James J.
Title Are branched chain fatty acids the natural substrates for P450(BM3)?
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
Publication date 2006
Sub-type Article (original research)
DOI 10.1039/b601202g
Issue 22
Start page 2353
End page 2355
Total pages 3
Place of publication Cambridge
Publisher Royal Society of Chemistry
Collection year 2006
Language eng
Subject C1
250302 Biological and Medical Chemistry
780103 Chemical sciences
Abstract Branched chain fatty acids are substrates for cytochrome P450(BM3) (CYP102) from Bacillus megaterium; oxidation of C-15 and C-17 iso and anteiso fatty acids by P450(BM3) leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.
Keyword Chemistry, Multidisciplinary
Bacillus-megaterium
Cytochromes P450
Subtilis
Purification
Cyclopropyl
Expression
Reduction
Oxidation
Alcohols
Ketones
Q-Index Code C1
Additional Notes DOI: 10.1039/b601202g

 
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