A golden age of human pigmentation genetics

Sturm, Richard A. (2006) A golden age of human pigmentation genetics. Trends In Genetics, 22 9: 464-468. doi:10.1016/j.tig.2006.06.010


Author Sturm, Richard A.
Title A golden age of human pigmentation genetics
Journal name Trends In Genetics   Check publisher's open access policy
ISSN 0168-9525
Publication date 2006
Sub-type Article (original research)
DOI 10.1016/j.tig.2006.06.010
Volume 22
Issue 9
Start page 464
End page 468
Total pages 5
Editor Treasa Creavin
Place of publication London
Publisher Elsevier Science London
Collection year 2006
Language eng
Subject C1
270204 Anthropological Genetics
730117 Skin and related disorders
Abstract The zebrafish golden mutation is characterized by the production of small and irregular-shaped melanin granules, resulting in a lightening of the pigmented lateral stripes of the animal. The recent positional cloning and localization of the golden gene, combined with genotype-phenotype correlations of alleles of its human orthologue (SLC24A5) in African-American and African-Caribbean populations, provide insights into the genetic and molecular basis of human skin colour. SLC24A5 promotes melanin deposition through maturation of the melanosome, highlighting the importance of ion-exchange in the function of this organelle.
Keyword Golden Gene
Pigmentation
Skin Colour
Genetics & Heredity
Recent Positive Selection
Skin Color
Human Genome
Identification
Exchanger
Locus
Map
Q-Index Code C1
Additional Notes DOI: 10.1016/j.tig.2006.06.010

 
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Created: Wed, 15 Aug 2007, 08:17:48 EST