Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q

Luciano, M., Wright, M. J., Duffy, D. L., Wainwright, M. A., Zhu, G., Evans, D. M., Geffen, G. M., Montgomery, G. W. and Martin, N. G. (2006) Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q. Behavior Genetics, 36 1: 45-55. doi:10.1007/s10519-005-9003-1


Author Luciano, M.
Wright, M. J.
Duffy, D. L.
Wainwright, M. A.
Zhu, G.
Evans, D. M.
Geffen, G. M.
Montgomery, G. W.
Martin, N. G.
Title Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1007/s10519-005-9003-1
Volume 36
Issue 1
Start page 45
End page 55
Total pages 11
Place of publication New York, NY, United States
Publisher Springer New York
Collection year 2006
Language eng
Subject C1
389999 Other Behavioural and Cognitive Sciences
730299 Public health not elsewhere classified
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2-5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score > 2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.
Keyword Cognitive Abilities
Genome-wide linkage
IQ
Reading ability
Twins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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Created: Wed, 15 Aug 2007, 08:17:27 EST