A genome scan for epidermal skin pattern in adolescent twins reveals suggestive linkage on 12p13.31

Shekar, Sri Niranjan, Duffy, David L., Montgomery, Grant W. and Martin, Nicholas G. (2006) A genome scan for epidermal skin pattern in adolescent twins reveals suggestive linkage on 12p13.31. Journal of Investigative Dermatology, 126 2: 277-282.


Author Shekar, Sri Niranjan
Duffy, David L.
Montgomery, Grant W.
Martin, Nicholas G.
Title A genome scan for epidermal skin pattern in adolescent twins reveals suggestive linkage on 12p13.31
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 0022-202X
1523-1747
Publication date 2006
Sub-type Article (original research)
DOI 10.1038/sj.jid.5700067
Volume 126
Issue 2
Start page 277
End page 282
Total pages 6
Editor L. Goldsmith
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2006
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Deterioration in stratum corneum reticular patterning (skin pattern or skin wrinkling) has been associated with increased rates of solar keratoses and skin cancer. A previous analysis of data from the twin sample used in this investigation has shown that 86% of the variation in skin pattern is genetic at age 12 and 62% in an adult sample (mean age 47.5). Variation due to genetic influences is likely to be influenced by more than one locus. Here, we present results of a genome-wide linkage scan of skin pattern in adolescent twins and siblings from 428 nuclear twin families. Sib-pair linkage analysis was performed on skin pattern data collected from twins at age 12 (378 informative families) and 14 (316 families). Suggestive linkage was found at marker D12S397 (12p13.31, logarithm of the odds (lod) 1.94), when the effect of the trait locus was modelled to influence the skin pattern equally at both ages 12 and 14. In the same analysis, a peak was seen at 4q23 with a lod score of 1.55. A possible candidate for the peak at 12p13.31 is the protease inhibitor, alpha-2-macroglobulin.
Keyword Dermatology
Variance-components
Alpha-2-macroglobulin
Gene
Microtopography
Melanoma
Traits
Locus
Qtl
Association
Inhibition
Q-Index Code C1
Institutional Status Non-UQ

 
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Created: Wed, 15 Aug 2007, 08:16:42 EST