Dissolution of porcine incisor pulps in sodium hypochlorite solutions of varying compositions and concentrations

Clarkson, R. M., Moule, A. J., Podlich, H., Kellaway, R., Macfarlane, R., Lewis, D. and Rowell, J. (2006) Dissolution of porcine incisor pulps in sodium hypochlorite solutions of varying compositions and concentrations. Australian Dental Journal, 51 3: 245-251. doi:10.1111/j.1834-7819.2006.tb00437.x

Author Clarkson, R. M.
Moule, A. J.
Podlich, H.
Kellaway, R.
Macfarlane, R.
Lewis, D.
Rowell, J.
Title Dissolution of porcine incisor pulps in sodium hypochlorite solutions of varying compositions and concentrations
Journal name Australian Dental Journal   Check publisher's open access policy
ISSN 0045-0421
Publication date 2006-09
Sub-type Article (original research)
DOI 10.1111/j.1834-7819.2006.tb00437.x
Volume 51
Issue 3
Start page 245
End page 251
Total pages 7
Editor P. M. Bartold
Place of publication Australia
Publisher Australian Dental Association Inc.
Collection year 2006
Language eng
Subject C1
730112 Oro-dental and disorders
320899 Dentistry not elsewhere classified
Abstract Background: The solubility of dental pulp tissue in sodium hypochlorite has been extensively investigated but results have been inconsistent; due most likely to variations in experimental design, the volume and/or rate of replenishment of the solutions used and the nature of the tissues assessed. Traditionally, the sodium hypochlorite solutions used for endodontic irrigation in Australia have been either Milton or commercial bleach, with Milton being the most common. Recently, a range of Therapeutic Goods Administration (TGA) approved proprietary sodium hypochlorite solutions, which contain surfactant, has become available. Some domestic chlorine bleaches now also contain surfactants. The purpose of this study was to perform new solubility assessments, comparing Milton with new TGA approved products, Hypochlor 1% and Hypochlor 4% forte, and with a domestic bleach containing surfactant (White King). Methods: Ten randomly assigned pulp samples of porcine dental pulp of approximately equal dimensions were immersed in the above solutions, as well as representative concentrations of sodium hydroxide. Time to complete dissolution was measured and assessed statistically. Results: White King 4% showed the shortest dissolution time, closely followed by Hypochlor 4% forte. White King 1% and Hypochlor 1% each took around three times as long to completely dissolve the samples of pulp as their respective 4% concentrations, while Milton took nearly 10 times as long. The sodium hydroxide solutions showed no noticeable dissolution of the pulp samples. Conclusions: The composition and content of sodium hypochlorite solutions had a profound effect on the ability of these solutions to dissolve pulp tissue in vitro. Greater concentrations provided more rapid dissolution of tissue. One per cent solutions with added surfactant and which contained higher concentrations of sodium hydroxide were significantly more effective in dissolution of pulp tissue than Milton.
Keyword Dentistry, Oral Surgery & Medicine
Endodontic Irrigating Solutions
Sodium Hypochlorite
Dental Pulp Solubility
Scanning Electron-microscope
Chloromethyl Methyl-ether
Endodontic Irrigant
Calcium Hydroxide
Solvent Action
Bovine Pulp
Tissue Dissolution
Necrotic Tissue
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 08:13:42 EST