Biocompatible properties of surgical mesh using an animal model

Krause, HG, Galloway, SJ, Khoo, SK, Lourie, R and Goh, JTW (2006) Biocompatible properties of surgical mesh using an animal model. Australian & New Zealand Journal of Obstetrics & Gynaecology, 46 1: 42-45. doi:10.1111/j.1479-828X.2006.00513.x

Author Krause, HG
Galloway, SJ
Khoo, SK
Lourie, R
Goh, JTW
Title Biocompatible properties of surgical mesh using an animal model
Journal name Australian & New Zealand Journal of Obstetrics & Gynaecology   Check publisher's open access policy
ISSN 0004-8666
Publication date 2006
Sub-type Article (original research)
DOI 10.1111/j.1479-828X.2006.00513.x
Volume 46
Issue 1
Start page 42
End page 45
Total pages 4
Editor M. Humphrey
Place of publication Carlton South, Australia
Publisher Blackwell Publishing Asia
Collection year 2006
Language eng
Subject C1
321014 Obstetrics and Gynaecology
730201 Women's health
Abstract To study the biocompatibility of surgical meshes for use in pelvic reconstructive surgery using an animal model. Eight different types of mesh: Atrium, Dexon, Gynemesh, IVS tape, Prolene, SPARC tape, TVT tape and Vypro II, were implanted into the abdominal walls of rats for 3 months' duration. Explanted meshes were assessed, using light microscopy, for parameters of rejection and incorporation. Type 1 (Atrium, Gynemesh, Prolene, SPARC and TVT) and type 3 (Vypro II, Dexon and IVS) meshes demonstrated different biocompatible properties. Inflammatory cellular response and fibrosis at the interface of mesh and host tissue was most marked with Vypro II and IVS. All type 1 meshes displayed similar cellular responses despite markedly different mesh architecture. The inflammatory response and fibrous reaction in the non-absorbable type 3 meshes tested (IVS and Vypro II) was more marked than the type 1 meshes. The increased inflammatory and fibrotic response may be because of the multifilamentous polypropylene components of these meshes. Material and filament composition of mesh is the main factor in determining cellular response.
Keyword Obstetrics & Gynecology
Animal Model
Surgical Mesh
Randomized Trial
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 08:02:59 EST