Mechanisms of axon guidance in the developing nervous system

Plachez, C. and Richards, L. J. (2005) Mechanisms of axon guidance in the developing nervous system. Current Topics In Developmental Biology, 69 267-346. doi:10.1016/S0070-2153(05)69010-2


Author Plachez, C.
Richards, L. J.
Title Mechanisms of axon guidance in the developing nervous system
Journal name Current Topics In Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1016/S0070-2153(05)69010-2
Volume 69
Start page 267
End page 346
Total pages 80
Place of publication San Diego
Publisher Elsevier Academic Press Inc
Collection year 2005
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract The human brain assembles an incredible network of over a billion neurons. Understanding how these connections form during development in order for the brain to function properly is a fundamental question in biology. Much of this wiring takes place during embryonic development. Neurons are generated in the ventricular zone, migrate out, and begin to differentiate. However, neurons are often born in locations some distance from the target cells with which they will ultimately form connections. To form connections, neurons project long axons tipped with a specialized sensing device called a growth cone. The growing axons interact directly with molecules within the environment through which they grow. In order to find their targets, axonal growth cones use guidance molecules that can either attract or repel them. Understanding what these guidance cues are, where they are expressed, and how the growth cone is able to transduce their signal in a directionally specific manner is essential to understanding how the functional brain is constructed. In this chapter, we review what is known about the mechanisms involved in axonal guidance. We discuss how the growth cone is able to sense and respond to its environment and how it is guided by pioneering cells and axons. As examples, we discuss current models for the development of the spinal cord, the cerebral cortex, and the visual and olfactory systems. (c) 2005, Elsevier Inc.
Keyword Developmental Biology
Growth Cone Guidance
Cell-adhesion Molecules
Putative Pheromone Receptors
Mouse Optic Chiasm
Chondroitin Sulfate Proteoglycans
Primary Olfactory Axons
Nuclear Factor-i
Rat Spinal-cord
Extracellular-matrix Molecules
Chemorepellent Semaphorin-iii
Q-Index Code C1
Additional Notes This document is a journal review.

 
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Created: Wed, 15 Aug 2007, 17:49:23 EST