Information integration in molecular bioscience

Garcia Castro, Alexander, Chen, Yi-Ping Phoebe and Ragan, Mark A. (2005) Information integration in molecular bioscience. Applied Bioinformatics, 4 3: 157-173. doi:10.2165/00822942-200594030-00001

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Author Garcia Castro, Alexander
Chen, Yi-Ping Phoebe
Ragan, Mark A.
Title Information integration in molecular bioscience
Journal name Applied Bioinformatics   Check publisher's open access policy
ISSN 1175-5636
Publication date 2005
Sub-type Article (original research)
DOI 10.2165/00822942-200594030-00001
Volume 4
Issue 3
Start page 157
End page 173
Total pages 17
Place of publication Auckland, N.Z.
Publisher Open Mind Journals
Collection year 2005
Language eng
Subject C1
280103 Information Storage, Retrieval and Management
780105 Biological sciences
Abstract Integrating information in the molecular biosciences involves more than the cross-referencing of sequences or structures. Experimental protocols, results of computational analyses, annotations and links to relevant literature form integral parts of this information, and impart meaning to sequence or structure. In this review, we examine some existing approaches to integrating information in the molecular biosciences. We consider not only technical issues concerning the integration of heterogeneous data sources and the corresponding semantic implications, but also the integration of analytical results. Within the broad range of strategies for integration of data and information, we distinguish between platforms and developments. We discuss two current platforms and six current developments, and identify what we believe to be their strengths and limitations. We identify key unsolved problems in integrating information in the molecular biosciences, and discuss possible strategies for addressing them including semantic integration using ontologies, XML as a data model, and graphical user interfaces as integrative environments.
Keyword Bioinformatics
Computers
Genomics
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 07:44:26 EST