Ras signaling from plasma membrane and endomembrane microdomains

Plowman, S. J. and Hancock, J. F. (2005) Ras signaling from plasma membrane and endomembrane microdomains. BBA: Molecular Cell Research, 1746 3: 274-283. doi:10.1016/j.bbamcr.2005.06.004


Author Plowman, S. J.
Hancock, J. F.
Title Ras signaling from plasma membrane and endomembrane microdomains
Journal name BBA: Molecular Cell Research   Check publisher's open access policy
ISSN 0167-4889
Publication date 2005-12-30
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbamcr.2005.06.004
Volume 1746
Issue 3
Start page 274
End page 283
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2005
Language eng
Subject C1
270104 Membrane Biology
780106 Political science and public policy
Formatted abstract
Ras proteins are compartmentalized by dynamic interactions with both plasma membrane microdomains and intracellular membranes. The mechanisms underlying Ras compartmentalization involve a series of protein/lipid, lipid/lipid and cytoskeleton interactions, resulting in the generation of discrete microdomains from which Ras operates. Segregation of Ras proteins to these different platforms regulates the formation of Ras signaling complexes and the generation of discrete signal outputs. This temporal and spatial modulation of Ras signal transduction provides a mechanism for the generation of different biological outcomes from different Ras isoforms, as well as flexibility in the signal output from a single activated isoform.
Keyword Biochemistry & Molecular Biology
Cell Biology
Ras
Microdomain
Lipid Raft
Acylation
Plasma Membrane
Endomembrane
H-ras
K-ras
N-ras
Single-molecule
Phosphoinositide 3-kinase
Lipid Rafts
Endoplasmic-reticulum
Living Cells
Hypervariable Region
Phosphatidic-acid
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 07:07:03 EST