The adult mouse hippocampal progenitor is neurogenic but not a stem cell

Bull, N. D. and Bartlett, P. F. (2005) The adult mouse hippocampal progenitor is neurogenic but not a stem cell. Journal of Neuroscience, 25 47: 10815-10821. doi:10.1523/JNEUROSCI.3249-05.2005

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ77393_OA.pdf Full text (open access) application/pdf 369.58KB 0

Author Bull, N. D.
Bartlett, P. F.
Title The adult mouse hippocampal progenitor is neurogenic but not a stem cell
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2005
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.3249-05.2005
Open Access Status File (Publisher version)
Volume 25
Issue 47
Start page 10815
End page 10821
Total pages 7
Editor Gary L. Westbrook
Place of publication Washington D.C.
Publisher The Society for Neuroscience
Collection year 2005
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract The aim of this investigation was to characterize the proliferative precursor cells in the adult mouse hippocampal region. Given that a very large number of new hippocampal cells are generated over the lifetime of an animal, it is predicted that a neural stem cell is ultimately responsible for maintaining this genesis. Although it is generally accepted that a proliferative precursor resides within the hippocampus, contradictory reports exist regarding the classification of this cell. Is it a true stem cell or a more limited progenitor? Using a strict functional definition of a neural stem cell and a number of in vitro assays, we report that the resident hippocampal precursor is a progenitor capable of proliferation and multipotential differentiation but is unable to self-renew and thus proliferate indefinitely. Furthermore, the mitogen FGF-2 stimulates proliferation of these cells to a greater extent than epidermal growth factor ( EGF). In addition, we found that BDNF was essential for the production of neurons from the hippocampal progenitor cells, being required during proliferation to trigger neuronal fate. In contrast, a bona fide neural stem cell was identified in the lateral wall of the lateral ventricle surrounding the hippocampus. Interestingly, EGF proved to be the stronger mitogenic factor for this cell, which was clearly a different precursor from the resident hippocampal progenitor. These results suggest that the stem cell ultimately responsible for adult hippocampal neurogenesis resides outside the hippocampus, producing progenitor cells that migrate into the neurogenic zones and proliferate to produce new neurons and glia.
Keyword Neurosciences
Lateral Ventricle
Neural Stem Cell
Adult Neurogenesis
Dentate Gyrus
Subventricular Zone
Neurotrophic Factor
Neural Progenitors
Brain Injury
Q-Index Code C1

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 164 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 179 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 07:04:12 EST