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Adequate primaquine for vivax malaria
Kitchener, S., Nasveld, P., Bennett, S. and Torresi, J. (2005-05) Adequate primaquine for vivax malaria. Journal of Travel Medicine, 12 3: 133-135.
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| Author(s) |
Kitchener, S.
Nasveld, P.
Bennett, S.
Torresi, J.
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| Title |
Adequate primaquine for vivax malaria
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| Journal name |
Journal of Travel Medicine
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| Publication date |
2005-05
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| Volume number |
12
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| Issue number |
3
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| ISSN |
1195-1982
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| Start page |
133
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| End page |
135
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| Total pages |
3
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| Editor(s) |
Robert Steffen
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| Place of publication |
Canada
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| Publisher |
B. C. Decker Inc.
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| Collection year |
2005
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| Language |
eng
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| Subject |
CX
320599 Pharmacology not elsewhere classified
730299 Public health not elsewhere classified
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| Abstract |
Background. Treatment of vivax malaria with primaquine prevents the relapse of infection from residual liver stages of the parasite. Inadequate dosage is related to a higher relapse risk. Methods: A comparison was made of vivax malaria relapse-prevention treatments with primaquine 22.5 mg or 30 mg daily for 14 days on 146 reports to the Australian Army Central Malaria Register. Results: The lower dose of primaquine was found to carry a relative risk of 6.63 for a relapse of vivax malaria compared with the higher dose. Conclusions:The available data presented here suggest that vivax malaria in this region is increasingly tolerant of the 22.5 mg daily treatment regimen of primaquine and that the greater dose of at least 30 mg daily is more effective.
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| Keyword(s) |
Medicine, General & Internal
Plasmodium-vivax
Radical Cure
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