Understanding the phylogeographic patterns of European hedgehogs, Erinaceus concolor and E-europaeus using the MHC

Berggren, K. T., Ellegren, H., Hewitt, G. M. and Seddon, J. M. (2005) Understanding the phylogeographic patterns of European hedgehogs, Erinaceus concolor and E-europaeus using the MHC. Heredity, 95 1: 84-90. doi:10.1038/sj.hdy.6800694


Author Berggren, K. T.
Ellegren, H.
Hewitt, G. M.
Seddon, J. M.
Title Understanding the phylogeographic patterns of European hedgehogs, Erinaceus concolor and E-europaeus using the MHC
Journal name Heredity   Check publisher's open access policy
ISSN 0018-067X
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1038/sj.hdy.6800694
Volume 95
Issue 1
Start page 84
End page 90
Total pages 7
Editor Richard A. Nichols
Place of publication UK
Publisher Nature Publishing Group
Collection year 2005
Language eng
Subject C1
270203 Population and Ecological Genetics
770703 Living resources (flora and fauna)
Abstract The genome of the European hedgehog, Erinaceus concolor and E. europaeus, shows a strong signal of cycles of restriction to glacial refugia and postglacial expansion. Patterns of expansion, however, differ for mitochondrial DNA (mtDNA) and preliminary analysis of nuclear markers. In this study, we determine phylogeographic patterns in the hedgehog using two loci of the major histocompatibility complex (MHC), isolated for the first time in hedgehogs. These genes show long persistence times and high polymorphism in many species because of the actions of balancing selection. Among 84 individuals screened for variation, only two DQA alleles were identified in each species, but 10 DQB alleles were found in E. concolor and six in E. europaeus. A strong effect of demography on patterns of DQB variability is observed, with only weak evidence of balancing selection. While data from mtDNA clearly subdivide both species into monophyletic subgroups, the MHC data delineate only E. concolor into distinct subgroups, supporting the preliminary findings of other nuclear markers. Together with differences in variability, this suggests that the refugia history and/or expansion patterns of E. concolor and E. europaeus differ.
Keyword Genetics & Heredity
Balancing Selection
Dqa
Dqb
Hedgehog
Mhc
Postglacial Colonisation
Major Histocompatibility Complex
Nucleotide Substitution
Overdominant Selection
Mammalian Hibernation
Ice Ages
Polymorphism
Loci
Evolution
Colonization
Beta
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 16:53:27 EST