Vaccination against fowl cholera with acapsular Pasteurella multocida A : 1

Chung, Jing Yeng, Wilkie, Ian, Boyce, John D. and Adler, Ben (2005) Vaccination against fowl cholera with acapsular Pasteurella multocida A : 1. Vaccine, 23 21: 2751-2755. doi:10.1016/j.vaccine.2004.11.036

Author Chung, Jing Yeng
Wilkie, Ian
Boyce, John D.
Adler, Ben
Title Vaccination against fowl cholera with acapsular Pasteurella multocida A : 1
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2005-04-15
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2004.11.036
Volume 23
Issue 21
Start page 2751
End page 2755
Total pages 5
Editor R. E. Spier
Place of publication Oxford, England
Publisher Elsevier
Collection year 2005
Language eng
Subject C1
300504 Immunology
630106 Poultry
11 Medical and Health Sciences
1107 Immunology
Abstract We have previously constructed an acapsular Pasteurella multocida X-73 (serogroup A) mutant strain which was attenuated in virulence for chickens (Chung JY, Wilkie IW, Boyce JD, Townsend KM, Frost AJ, Ghodussi M, Adler B. Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A. Infect. Immun. 2001;69:2487-2492). In this study, we have assessed the ability of this acapsular strain (PBA930) to induce protection against wild-type challenge in mice and the natural host chickens. Intramuscular administration of PBA930 to mice stimulated significant protection against X-73 and the heterologous strain P-1059 (A:3), but not against challenge with P-1662 (A:4). No protection was observed when PBA930 was introduced by the intraperitoneal or subcutaneous routes in mice. Significantly, the acapsular strain PBA930 was able to induce protection against challenge with wild type X-73 in chickens. (c) 2004 Elsevier Ltd. All rights reserved.
Keyword Immunology
Medicine, Research & Experimental
Veterinary Sciences
Pasteurella Multocida
Fowl Cholera
Acapsular Mutant
Protective Immunity
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 06:52:38 EST