Contribution of the collagen I alpha 1 and vitamin D receptor genes to the risk of hip fracture in elderly women

Nguyen, TV, Esteban, LM, White, CP, Grant, SF, Center, JR, Gardiner, EM and Eisman, JA (2005) Contribution of the collagen I alpha 1 and vitamin D receptor genes to the risk of hip fracture in elderly women. Journal of Clinical Endocrinology And Metabolism, 90 12: 6575-6579. doi:10.1210/jc.2005-1153


Author Nguyen, TV
Esteban, LM
White, CP
Grant, SF
Center, JR
Gardiner, EM
Eisman, JA
Title Contribution of the collagen I alpha 1 and vitamin D receptor genes to the risk of hip fracture in elderly women
Journal name Journal of Clinical Endocrinology And Metabolism   Check publisher's open access policy
ISSN 0021-972X
Publication date 2005
Sub-type Article (original research)
DOI 10.1210/jc.2005-1153
Volume 90
Issue 12
Start page 6575
End page 6579
Total pages 5
Editor J. Bilezikian
P. Meravy
Place of publication USA
Publisher The Endocrine Society
Collection year 2005
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract Context and Objective: Hip fracture is partially genetically determined. The present study was designed to examine the contributions of vitamin D receptor (VDR) and collagen I alpha 1 (COLIA1) genotypes to the liability to hip fracture in postmenopausal women. Design: The study was designed as a prospective population-based cohort investigation. Subjects: Six hundred seventy-seven postmenopausal women of Caucasian background, aged 70 +/- 7 yr (mean +/- SD), have been followed for up to 14 yr. Sixty-nine women had sustained a hip fracture during the period. Main Outcome: Atraumatic hip fractures were prospectively identified through radiologists' reports. Bone mineral density (BMD) at the hip and lumbar spine was measured by dual-energy x-ray absorptiometry. Genotypes: The TaqI and SpI COLIA1 polymorphisms of the VDR and COLIA1 genes were determined. Using the Single Nucleotide Polymorphism database, VDR TT, Tt, and tt genotypes were coded as TT, TC, and CC, whereas COLIA1 SS, Ss, and ss were coded as GG, GT, and TT. Results: Women with VDR CC genotype (16% prevalence) and COLIA1 TT genotype (5% prevalence) had an increased risk of hip fracture [odds ratio (OR) associated with CC, 2.6; 95% confidence interval (CI), 1.2-5.3; OR associated with TT, 3.8; 95% CI, 1.3-10.8] after adjustment for femoral neck BMD (OR, 3.4 per SD; 95% CI, 2.3-5.0) and age (OR, 1.4 per 5 yr; 95% CI, 1.1-1.7). Approximately 20 and 12% of the liability to hip fracture was attributable to the presence of the CC genotype and TT genotype, respectively. Conclusion: The VDR CC genotype and COLIA1 TT genotype were associated with increased hip fracture risk in Caucasian women, and this association was independent of BMD and age.
Keyword Endocrinology & Metabolism
Bone-mineral Density
Sp1 Binding-site
Osteoporotic Fractures
Postmenopausal Women
I-alpha-1 Gene
Polymorphisms
Population
Prediction
Alleles
Mass
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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Created: Wed, 15 Aug 2007, 06:49:38 EST