Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells

Wu, Hsing-Ju, Seib, Kate L., Edwards, Jennifer L., Apicella, Michael A., McEwan, Alastair G. and Jennings, Michael P. (2005) Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells. Infection And Immunity, 73 12: 8444-8448. doi:10.1128/IAI.73.12.8444-8448.2005

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Author Wu, Hsing-Ju
Seib, Kate L.
Edwards, Jennifer L.
Apicella, Michael A.
McEwan, Alastair G.
Jennings, Michael P.
Title Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells
Journal name Infection And Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1128/IAI.73.12.8444-8448.2005
Open Access Status File (Publisher version)
Volume 73
Issue 12
Start page 8444
End page 8448
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2005
Language eng
Abstract Laz, a lipid-modified azurin of the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis, is involved in defense against oxidative stress and copper toxicity; laz mutant strains are hypersensitive to hydrogen peroxide and copper. The N. gonorrhoeae laz mutant also has decreased survival in an ex vivo primary human ectocervical epithelial assay.
Keyword Immunology
Infectious Diseases
Suppressor Protein P53
Lipid-modified Azurin
Pseudomonas-aeruginosa
Superoxide-dismutase
Reactive Oxygen
H.8 Epitope
Gonorrhoeae
Meningitidis
Expression
Strain
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 06:48:30 EST