Outcomes of split versus reduced-size grafts in pediatric liver transplantation

Oswari, Hanifah, Lynch, Stephen V., Fawcett, Jonathan, Strong, Russell W. and Ee, Looi C. (2005) Outcomes of split versus reduced-size grafts in pediatric liver transplantation. Journal of Gastroenterology and Hepatology, 20 12: 1850-1854. doi:10.1111/j.1440-1746.2005.03926.x


Author Oswari, Hanifah
Lynch, Stephen V.
Fawcett, Jonathan
Strong, Russell W.
Ee, Looi C.
Title Outcomes of split versus reduced-size grafts in pediatric liver transplantation
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 0815-9319
1440-1746
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1746.2005.03926.x
Volume 20
Issue 12
Start page 1850
End page 1854
Total pages 5
Editor H. Ishii
R.K. Tandon
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2005
Language eng
Subject 321029 Surgery
730109 Surgical methods and procedures
Formatted abstract
Background:
Split-liver transplantation, where two grafts are created from a single donor organ, is a means of overcoming donor organ scarcity. There are few data comparing outcomes of split with reduced-size liver grafts, which is the most common type of cadaveric graft in pediatric liver transplantation. The aims of the present paper were to compare survival and complication rates between split and reduced-size cadaveric grafts in pediatric patients receiving a liver transplant in Brisbane.

Methods:

Review of the Queensland Liver Transplant Service database was undertaken. All pediatric patients who received either a cadaveric split or reduced-size graft between 1985 and 2000 were examined. The incidence of patient and graft survival, vascular complications and biliary complications were identified.

Results:

A total of 251 liver transplants were performed of which 138 were reduced-size grafts and 30 were split grafts. There were no differences in etiology of liver disease, mean age, weight, and urgency of transplant between the two groups. One-year patient and graft survivals were comparable at 73% and 67%, respectively, in both groups. There was no difference in the incidence of vascular complications between groups. Biliary complications were significantly more common after split grafts when compared with reduced-size grafts (21% vs 4%, P < 0.0001) but did not affect patient or graft survival.

Conclusions:

Survival and vascular complications after split-liver grafts were comparable to outcomes after reduced-size grafts. Biliary complications occur more commonly with split-liver grafts but did not affect patient or graft survival. It is recommended that every pediatric recipient be considered for a split-liver graft. (C) 2005 Blackwell Publishing Asia Pty Ltd.
Keyword Gastroenterology & Hepatology
Liver Transplant
Outcomes
Pediatrics
Split-liver Graft
Waiting-list
Survival
Children
Vivo
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 16:45:27 EST