Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel((R))

Dansirikul, Chantaratsamon, Choi, Malcolm and Duffull, Stephen B. (2005) Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel((R)). Computers in Biology and Medicine, 35 5: 389-403. doi:10.1016/j.compbiomed.2004.02.008

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Dansirikul, Chantaratsamon
Choi, Malcolm
Duffull, Stephen B.
Title Estimation of pharmacokinetic parameters from non-compartmental variables using Microsoft Excel((R))
Journal name Computers in Biology and Medicine   Check publisher's open access policy
ISSN 0010-4825
1879-0534
Publication date 2005-06
Sub-type Article (original research)
DOI 10.1016/j.compbiomed.2004.02.008
Volume 35
Issue 5
Start page 389
End page 403
Total pages 15
Editor R. S. Ledley
B. V. Mossman
Place of publication Oxon, United Kingdom
Publisher Pergamon
Collection year 2005
Language eng
Subject C1
320503 Clinical Pharmacology and Therapeutics
730299 Public health not elsewhere classified
Abstract This study was conducted to develop a method, termed 'back analysis (BA)', for converting non-compartmental variables to compartment model dependent pharmacokinetic parameters for both one- and two-compartment models. A Microsoft Excel((R)) spreadsheet was implemented with the use of Solver((R)) and visual basic functions. The performance of the BA method in estimating pharmacokinetic parameter values was evaluated by comparing the parameter values obtained to a standard modelling software program, NONMEM, using simulated data. The results show that the BA method was reasonably precise and provided low bias in estimating fixed and random effect parameters for both one- and two-compartment models. The pharmacokinetic parameters estimated from the BA method were similar to those of NONMEM estimation.
Keyword Non-compartmental variables
Compartment model parameters
Pharmacokinetic parameters
Microsoft Excel((r))
Solver((r))
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 06:43:29 EST