Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients

Waterhouse, T. H., Redmann, S., Duffull, S. B. and Eccleston, J. A. (2005) Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients. Journal of Pharmacokinetics And Pharmacodynamics, 32 3-4: 521-545. doi:10.1007/s10928-005-0026-2


Author Waterhouse, T. H.
Redmann, S.
Duffull, S. B.
Eccleston, J. A.
Title Optimal design for model discrimination and parameter estimation for itraconazole population pharmacokinetics in cystic fibrosis patients
Journal name Journal of Pharmacokinetics And Pharmacodynamics   Check publisher's open access policy
ISSN 1567-567X
Publication date 2005
Sub-type Article (original research)
DOI 10.1007/s10928-005-0026-2
Volume 32
Issue 3-4
Start page 521
End page 545
Total pages 25
Editor L. Aarons
M. Rowland
T. Ludden
W.J. Jusko
Place of publication New York
Publisher Kluwer Academic/Plenum.
Collection year 2005
Language eng
Subject C1
320403 Medical Infection Agents (incl. Prions)
730399 Health and support services not elsewhere classified
Abstract Optimal sampling times are found for a study in which one of the primary purposes is to develop a model of the pharmacokinetics of itraconazole in patients with cystic fibrosis for both capsule and solution doses. The optimal design is expected to produce reliable estimates of population parameters for two different structural PK models. Data collected at these sampling times are also expected to provide the researchers with sufficient information to reasonably discriminate between the two competing structural models.
Keyword Pharmacology & Pharmacy
Itraconazole
Optimal Design
Model Discrimination
Pharmacokinetic Modelling
Population Approach
Allergic Bronchopulmonary Aspergillosis
Steady-state Pharmacokinetics
Healthy-volunteers
Food Interaction
Hydroxyitraconazole
Absorption
Clearance
Capsules
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 06:43:16 EST