Adipose tissue from pregnant women with and without gestational diabetes mellitus: Insulin-sensitive but resistant to hyperosmolarity

Russell, Anthony W., McIntyre, H. David, Whitehead, Jon P. and Prins, Johannes B. (2005) Adipose tissue from pregnant women with and without gestational diabetes mellitus: Insulin-sensitive but resistant to hyperosmolarity. American Journal of Obstetrics and Gynecology, 193 6: 2017-2023. doi:10.1016/j.ajog.2005.04.058


Author Russell, Anthony W.
McIntyre, H. David
Whitehead, Jon P.
Prins, Johannes B.
Title Adipose tissue from pregnant women with and without gestational diabetes mellitus: Insulin-sensitive but resistant to hyperosmolarity
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1016/j.ajog.2005.04.058
Volume 193
Issue 6
Start page 2017
End page 2023
Total pages 7
Editor M. H. Kim
T. J. Garite
Place of publication USA
Publisher Mosby
Collection year 2005
Language eng
Subject C1
321014 Obstetrics and Gynaecology
730105 Endocrine organs and diseases (incl. diabetes)
Formatted abstract
Objective: We sought to determine the contribution of adipose tissue to the insulin resistance of pregnancy. We also investigated whether hyperosmolar stress (induced by sorbitol) stimulates glucose uptake in human adipose tissue and, if so, whether this effect is altered in pregnancy and gestational diabetes mellitus.

Study design
: Subcutaneous and omental adipose tissue biopsy specimens were obtained at elective abdominal surgery or cesarean delivery from 16 normal glucose-tolerant pregnant women, 13 pregnant women with gestational diabetes mellitus, and 19 body mass index–matched nonpregnant control subjects. Basal, insulin (100 nmol/L)-, and sorbitol (250 mmol/L)-stimulated glucose uptake levels were measured.

Results
: Basal and insulin-stimulated glucose uptake into adipose tissue was not impaired in pregnancy or gestational diabetes mellitus compared with control subjects. Hyperosmolarity stimulated glucose uptake in human adipose tissue from the subcutaneous, but not omental depot, and not in adipose tissue from pregnant subjects.

Conclusion
: There is no significant difference in insulin sensitivity in adipose tissue from pregnant or nonpregnant women; hyperosmolarity stimulates glucose uptake in subcutaneous adipose tissue from nonpregnant women, and adipose tissue from pregnant women is sorbitol resistant. These findings suggest the phosphotidylinositol 3-kinase–independent pathway may have pathophysiologic relevance to glucose uptake in human adipose tissue and may be impaired in pregnancy.
Keyword Obstetrics & Gynecology
Adipocyte
Pregnancy
Gestational Diabetes Mellitus
Glucose Uptake
Sorbitol
Glucose-transport
Glut4 Translocation
Receptor Binding
Adipocytes
Defects
Society
System
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 16:39:07 EST