In vitro bioassay as a predictor of in vivo response

Barnard, R. T. and Gurevich, K. (2005) In vitro bioassay as a predictor of in vivo response. Theoretical Biology and Medical Modelling, 2 3.1-3.8. doi:10.1186/1742-4682-2-3

Author Barnard, R. T.
Gurevich, K.
Title In vitro bioassay as a predictor of in vivo response
Journal name Theoretical Biology and Medical Modelling   Check publisher's open access policy
ISSN 1742-4682
Publication date 2005
Sub-type Article (original research)
DOI 10.1186/1742-4682-2-3
Open Access Status DOI
Volume 2
Start page 3.1
End page 3.8
Total pages 8
Place of publication United Kingdom
Publisher Biomed Central
Collection year 2005
Language eng
Subject C1
239901 Biological Mathematics
780105 Biological sciences
Abstract Background There is a substantial discrepancy between in vitro and in vivo experiments. The purpose of the present work was development of a theoretical framework to enable improved prediction of in vivo response from in vitro bioassay results. Results For dose-response curve reaches a plateau in vitro we demonstrated that the in vivo response has only one maximum. For biphasic patterns of biological response in vitro both the bimodal and biphasic in vivo responses might be observed. Conclusion As the main result of this work we have demonstrated that in vivo responses might be predicted from dose-effect curves measured in vitro.
Keyword Bioassay
In vivo results
In vitro results
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article number 3

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Created: Wed, 15 Aug 2007, 06:33:43 EST