How an enzyme answers. multiple-choice questions

McCourt, J. A. and Duggleby, R. G. (2005) How an enzyme answers. multiple-choice questions. Trends In Biochemical Sciences, 30 5: 222-225. doi:10.1016/j.tibs.2005.03.006


Author McCourt, J. A.
Duggleby, R. G.
Title How an enzyme answers. multiple-choice questions
Journal name Trends In Biochemical Sciences   Check publisher's open access policy
ISSN 0968-0004
0376-5067
Publication date 2005-05
Sub-type Article (original research)
DOI 10.1016/j.tibs.2005.03.006
Volume 30
Issue 5
Start page 222
End page 225
Total pages 4
Place of publication Amsterdam
Publisher Elsevier
Collection year 2005
Language eng
Subject C1
270108 Enzymes
780105 Biological sciences
0304 Medicinal and Biomolecular Chemistry
0601 Biochemistry and Cell Biology
Abstract Acetohydroxyacid synthase (AHAS) is the first common enzyme in the pathway for the biosynthesis of branched-chain amino acids. Interest in the enzyme has escalated over the past 20 years since it was discovered that AHAS is the target of the sulfonylurea and imidazolinone herbicides. However, several questions regarding the reaction mechanism have remained unanswered, particularly the way in which AHAS I chooses' its second substrate. A new method for the detection of reaction intermediates enables calculation of the microscopic rate constants required to explain this phenomenon.
Keyword Biochemistry & Molecular Biology
Acetohydroxy Acid Synthase
Physiological Implications
Escherichia-coli
Biosynthesis
Diphosphate
Substrate
Mechanism
Nmr
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 06:33:27 EST