Drugs to treat inflammation: A historical introduction

Whitehouse, Michael W. (2005) Drugs to treat inflammation: A historical introduction. Current Medicinal Chemistry, 12 25: 2931-2942. doi:10.2174/092986705774462879

Author Whitehouse, Michael W.
Title Drugs to treat inflammation: A historical introduction
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/092986705774462879
Volume 12
Issue 25
Start page 2931
End page 2942
Total pages 12
Editor A. Rahman
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2005
Language eng
Subject C1
320599 Pharmacology not elsewhere classified
730100 Clinical (Organs, Diseases and Abnormal Conditions)
03 Chemical Sciences
0304 Medicinal and Biomolecular Chemistry
Abstract Drugs to treat inflammation are discussed under the following headings: (1) random discoveries covering copper, salicylates, heterocyclic diones, ACTH, adrenal steroids and disease-modifying agents (DMARDs); these include Au(I)-thiolates, chloroquine, and hydroxychloroquine, minocycline, cyclosporin, salazopyrine, D-penicillamine and methotrexate; (2) programmed NSAID developments covering salicylates and fenamates, arylalkanoates, diones, non-acidic NSAIDs, clozic, lobenzarit and coxibs; (3) synthetic glucocorticosteroids; and (4) 'Biologicals' for neutralising pro-inflammatory cytokines. Clinical problems are highlighted, particularly unacceptable side-effects affecting the GI tract, skin, liver, etc. that caused many drugs to be withdrawn. Drug combinations may overcome some of these problems. The bibliography has selected reviews and monographs covering 50 years of publications.
Keyword Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
Combination Therapies
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 06:29:54 EST